| ncRNA name | IL17RC siRNA |
| ncRNA Category | siRNA |
| Disease name | age-related macular degeneration (AMD) |
| Species | Homo sapiens |
| Tissues/Cell_line | human RPE cell line ARPE-19 |
| Methods | qRT-PCR, immunohistochemistry, MTT assay, siRNA transfection, ELISA, Western blot |
| Expression pattern | associated |
| Functional description | In vitro, IL17A induces RPE cell death characterized by the accumulation of cytoplasmic lipids and autophagosomes with subsequent activation of pro-apoptotic Caspase-3 and Caspase-9. This pathology is reduced by siRNA knockdown of IL17RC. |
| PubMed ID | 24780906 |
| Year | 2014 |
| Title | Interleukin-17 retinotoxicity is prevented by gene transfer of a soluble interleukin-17 receptor acting as a cytokine blocker: implications for age-related macular degeneration. |
| Drug-related ncRNA | NO |
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